ISO 24276-2006 amd1-2013 PDF

Full title and description

St ISO 24276-2006 amd1-2013 — Foodstuffs — Methods of analysis for the detection of genetically modified organisms and derived products — General requirements and definitions — Amendment 1 (amends ISO 24276:2006 to provide clarifications and additional definitions and guidance for GMO detection methods in foodstuffs).

Abstract

This amendment (published April 2013) updates the 2006 International Standard by clarifying the introduction, definitions and how the parts of the horizontal GMO testing framework interrelate (extraction, qualitative and quantitative nucleic acid methods and protein‑based methods). It emphasizes common terminology (e.g. LOD/LOQ, repeatability, reproducibility), measurement uncertainty and validation expectations for methods used to detect and quantify GMOs and derived products in food matrices.

General information

• Status: Published (Amendment to ISO 24276:2006).
• Publication date: Original ISO 24276:2006 (February 2006); Amendment 1 published April 2013.
• Publisher: International Organization for Standardization (ISO).
• ICS / categories: 67.050 — General methods of tests and analysis for food products.
• Edition / version: ISO 24276:2006 + Amendment 1 (2013), Edition 1 (amendment published 2013-04).
• Number of pages: Amendment document: 11 pages (Amendment 1).

Scope

The amendment applies to ISO 24276:2006 and provides clarifications and additions to the standard’s introduction, terminology and normative relationships with related method standards. It specifies how to apply the horizontal series of standards for GMO testing (nucleic acid extraction, qualitative and quantitative nucleic acid methods and protein‑based methods) and gives guidance on validation, performance characteristics and reporting for analyses of GMOs and derived products in foodstuffs (and by extension seeds, feed and some environmental/plant samples).

Key topics and requirements

• Standardized definitions and terminology for GMO testing (e.g. screening vs. construct/event-specific methods, test sample/test portion, LOD, LOQ, trueness, precision).
• Relationships and application guidance for the related method standards (ISO 21571, ISO 21569, ISO 21570, ISO 21572) forming the horizontal GMO-testing framework.
• Performance characteristics and validation requirements: limits of detection and quantification, measurement uncertainty, repeatability and reproducibility expectations, and demonstration of fitness for purpose.
• Guidance on method description, laboratory set‑up, sample handling and reporting of results to support harmonized interpretation and regulatory compliance.
• Emphasis on use of collaborative trials or appropriate validation studies to substantiate method performance claims.

Typical use and users

Adopted by testing laboratories performing GMO screening, identification and quantification in raw materials, ingredients and finished foodstuffs; regulatory and food safety authorities; method developers and kit manufacturers validating nucleic acid‑ or protein‑based assays; accreditation and proficiency‑testing providers; and quality teams in food production and trade verifying labeling and supply‑chain compliance.

Related standards

Directly related to and intended to be used together with: ISO 21571 (nucleic acid extraction), ISO 21569 (qualitative nucleic acid based methods), ISO 21570 (quantitative nucleic acid based methods), ISO 21572 (protein‑based methods). Also related to measurement/validation standards such as ISO 5725 (accuracy — trueness and precision) and national/adopted versions (EN/ISO variants).

Keywords

GMO, genetically modified organisms, foodstuffs, detection, nucleic acid extraction, PCR, qualitative methods, quantitative methods, protein‑based detection, LOD, LOQ, validation, measurement uncertainty, ISO 24276.

FAQ

Q: What is this standard?

A: It is Amendment 1 (2013) to ISO 24276:2006 — a horizontal guidance document that sets general requirements and definitions for methods used to detect genetically modified organisms and derived products in foodstuffs.

Q: What does it cover?

A: It clarifies terminology, the relationships between extraction, qualitative and quantitative nucleic acid methods and protein‑based methods, and gives guidance on method validation, performance characteristics (LOD/LOQ, repeatability, reproducibility) and reporting for GMO analyses.

Q: Who typically uses it?

A: Food testing laboratories, regulators and food safety authorities, method and kit developers, accreditation bodies, proficiency‑testing providers, and food industry quality teams.

Q: Is it current or superseded?

A: The amendment was published in April 2013 and is the official amendment to ISO 24276:2006. ISO’s catalogue shows the original standard and its amendment as published and subject to periodic systematic review; however, some national adoptions or national catalogs may list the document as superseded at the national level. Users should check the ISO catalogue or their national standards body for the latest status in their country before relying on the document for regulatory purposes.

Q: Is it part of a series?

A: Yes — it is the general/introductory element of a horizontal set of standards for GMO detection (ISO 21571, ISO 21569, ISO 21570, ISO 21572 and related documents) that together cover extraction, qualitative and quantitative nucleic acid methods and protein‑based detection.

Q: What are the key keywords?

A: GMO, genetically modified organisms, foodstuffs, detection, PCR, nucleic acid extraction, LOD, LOQ, validation, measurement uncertainty, repeatability, reproducibility.