ISO 10298-2018 PDF

Full title and description

ISO 10298:2018 — Gas cylinders — Gases and gas mixtures — Determination of toxicity for the selection of cylinder valve outlets. This International Standard provides a consolidated listing of the best available acute inhalation-toxicity data for gases and vapours to support classification of gases and gas mixtures for inhalation toxicity so that appropriate cylinder valve outlets and associated safety measures can be selected.

Abstract

ISO 10298:2018 lists best-available acute-toxicity (inhalation) data drawn from current literature to enable classification of gases and gas mixtures by inhalation toxicity (for example LC50-based guidance) and to assist in selecting appropriate cylinder valve outlets and safety arrangements for the transport and use of compressed gases. The document was published as the third edition in 2018 and has a later amendment (Amd 1:2021) covering small updates.

General information

• Status: Published (current edition: 3rd edition, 2018; amended by ISO 10298:2018/Amd 1:2021).
• Publication date: February 12, 2018 (edition 3, 2018).
• Publisher: International Organization for Standardization (ISO).
• ICS / categories: 71.100.20 — Gases for industrial application.
• Edition / version: Edition 3 (2018); amended by ISO 10298:2018/Amd 1 (2021).
• Number of pages: 15 pages in the main 2018 edition (amendment is 1 page).

Scope

ISO 10298:2018 provides a literature-based roster of acute inhalation toxicity data for individual gases and selected vapours to be used when classifying pure gases and gas mixtures for their inhalation toxicity. The classification information is intended to inform the selection of cylinder valve outlets and related safety provisions for gas cylinders used in industry, laboratories and transport. The standard is produced by ISO/TC 58/SC 2 (cylinder fittings) and is intended specifically to support decisions about valve outlet selection based on toxicity hazards.

Key topics and requirements

• Consolidated acute inhalation-toxicity data (LC50 and equivalent measures) for gases and vapours to support toxicity classification for inhalation.
• Guidance for using toxicity classification to select suitable cylinder valve outlet types and safety measures.
• Reference to best-available literature sources and methodology for choosing representative toxicity values for pure gases and mixtures.
• Provides an annexed or tabulated listing (as applicable) of gases with associated toxicity data to simplify valve outlet selection decisions.
• Contains an amendment (Amd 1:2021) that updates or corrects specific entries without replacing the full standard.

Typical use and users

Typical users include gas cylinder manufacturers, gas suppliers, safety engineers, laboratory managers, transport and logistics personnel handling compressed gases, standardization bodies, and regulatory authorities. The standard is used when specifying or selecting cylinder valve outlets, preparing safety data and transport documentation, and when assessing handling and storage controls tied to inhalation toxicity hazards.

Related standards

ISO 10298:2018 supersedes ISO 10298:2010 (withdrawn) and has been issued with an amendment ISO 10298:2018/Amd 1:2021. The content is related to other ISO/TC 58 standards on cylinder fittings and gas properties; regional/adopted versions exist (for example EN ISO 10298:2020 in the European system). A draft/revision (ISO/DIS 10298) has been reported as under development in ISO portals.

Keywords

gas cylinders, gases, gas mixtures, inhalation toxicity, LC50, acute toxicity, cylinder valve outlets, cylinder fittings, ISO/TC 58, safety, valve selection.

FAQ

Q: What is this standard?

A: ISO 10298:2018 is an International Standard titled "Gas cylinders — Gases and gas mixtures — Determination of toxicity for the selection of cylinder valve outlets" that compiles acute inhalation-toxicity data to support valve outlet selection decisions for gas cylinders.

Q: What does it cover?

A: It covers the best-available acute inhalation-toxicity data (literature-derived values such as LC50 and equivalents) for gases and selected vapours, and provides guidance to classify gases/gas mixtures for inhalation toxicity to inform the selection of appropriate cylinder valve outlets and related safety arrangements.

Q: Who typically uses it?

A: Gas producers and suppliers, cylinder and valve manufacturers, safety and compliance officers, laboratory managers, transport/handling personnel, and standards bodies use this standard when specifying valves, assessing inhalation hazards, and preparing safety controls.

Q: Is it current or superseded?

A: The 2018 edition (3rd edition) is the current published edition and was confirmed in ISO reviews (ISO entry shows the 2018 edition as published and later reviewed); it is amended by ISO 10298:2018/Amd 1:2021. ISO records indicate a revision/draft (ISO/DIS 10298) was under development (i.e., slated for future revision), so users should check for any newer replacement or final revision beyond the 2018 edition and 2021 amendment before relying on the standard for regulatory compliance.

Q: Is it part of a series?

A: ISO 10298 has prior editions (1995, 2010) and the 2018 publication is the 3rd edition; it is produced under ISO/TC 58/SC 2 (cylinder fittings) and is related to other ISO standards on cylinders, fittings and gas properties. The 2018 edition also has an official amendment published in 2021.

Q: What are the key keywords?

A: Key keywords include: gas cylinders, gases, gas mixtures, inhalation toxicity, LC50, acute toxicity, cylinder valve outlets, valve fittings, ISO/TC 58.